Description

Function

1. Metabolic Role: TPP is an essential cofactor for enzymes involved in the metabolism of carbohydrates, branched-chain amino acids, and fatty acids. It is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex.
2. Energy Production: It supports oxidative phosphorylation and the pentose phosphate pathway, contributing to ATP production.
3. Neurological Function: TPP is vital for normal neurological function, as it helps maintain the health of nerve cells.
4. Cardiovascular Health: It plays a role in preventing cardiovascular issues related to thiamine deficiency, such as “wet beriberi” (a form of heart failure).

Application

1. Nutritional Supplements: TPP is used to treat or prevent thiamine deficiency, which can lead to conditions like beriberi and Wernicke-Korsakoff syndrome.
2. Medical Treatments: It is used in the treatment of neurological disorders, cardiovascular issues related to thiamine deficiency, and during cytostatic treatment.
3. Research: TPP is used as a research tool to study metabolic pathways and enzyme mechanisms.
4. Food Fortification: It can be added to food products to enhance their nutritional value.