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Vitamin K12 is a fat-soluble vitamin, which can be used for the treatment of coagulation disorders and the early prevention of bleeding in newborns. Vitamin K12 makes the carboxylase, which is present in hepatocyte microparticles and converts glutamic acid in the precursor of these factors into γ-carboxyglutamic acid, active.
In the absence of vitamin K12, glutamate in vitamin K12-dependent factor precursors cannot be carboxylated and therefore cannot bind to calcium ions, thus affecting their coagulation activity and clinical bleeding tendency.
2) Function& Application
Vitamin K12 can treat neonatal hemorrhagic disease, late onset vitamin K12 deficiency. This disease is common in infancy and is characterized by extensive bleeding and intracranial hemorrhage. Delayed treatment can lead to death or neurological sequelae. Vitamin K12 is required for the synthesis of coagulation factors by the liver in hepatocellular microsomes. Vitamin K12, also known as clotting vitamin, is more abundant in food, especially pig liver, soybean and green leaf food. Vitamin K12 is synthesized by bacteria in the human gut and absorbed by the gut.