L-Pyroglutamic Acid

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  • Brand: JHD Corp
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1)Product Description


L-Pyroglutamic acid is a 5-oxoproline. It is formed by dehydration between the α-NH2 group and the γ-hydroxyl group of glutamate to form an intramolecular amide bond; it can also be formed by the loss of the acylamino group within the glutamine molecule.

If glutathione synthetase is defective, pyroglutaminaemia can result, with a range of clinical symptoms.

Pyroglutaminemia is a disorder of organic acid metabolism caused by a defect in glutathione synthetase. Clinical manifestations 12 to 24 hours after birth onset, progressive haemolysis, jaundice, chronic metabolic acidosis, mental retardation; urine contains pyroglutamic acid, lactic acid, α-deoxy 4hydroxyacetoacetic acid endolipid. Treatment, symptomatic, post-week-old attention to diet regulation, etc.


Product Name

L-Pyroglutamic Acid




99% Above


Off-White/ White Fine Crystal


2) Function


Pyroglutamic acid is one of the main components of the skin's natural moisturizing factor, and its moisturizing ability far exceeds that of glycerin. It is non-toxic and non-irritating, and is an excellent raw material for modern skin care and hair care cosmetics. Pyroglutamic acid also has an inhibitory effect on the activity of tyrosine oxidase, thereby preventing the deposition of "melanoid" substances in the skin and has a whitening effect on the skin. It has a softening effect on keratin and can be used in nail cosmetics. In addition to its application in cosmetics, L-pyroglutamic acid can also form derivatives with other organic compounds, and has special effects in terms of surface activity, transparency and brightening effect. It can also be used as a surfactant for detergents; chemical reagents for the resolution of racemic amines; organic intermediates.       

3) Application 

Organic synthesis intermediates; food additives;

organic intermediates; organic chemical raw materials; chemical intermediates.

For treatment of surfaces of polycaprolactam products, enhances the thermal stability.

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