Acetyl-L-Carnitine (ALCAR) is an acetylated derivative of L-Carnitine, a naturally occurring compound that can cross the blood-brain barrier and has multiple physiological functions.
Acts as an acetyl donor to promote the transfer of fatty acids from the cytoplasm to the mitochondria, participating in the beta-oxidation of fatty acids to provide energy for cells.
Helps maintain the balance of coenzyme A and acetyl-CoA within cells, supporting normal energy metabolism.
Neuroprotection and Repair:
Exhibits neuroprotective effects by promoting nerve regeneration and axonal growth, improving nerve conduction velocity.
Shows significant protective effects in models of neurodegenerative diseases such as Alzheimer’s disease, ischemia-hypoxia, and traumatic brain injury.
Reduces oxidative stress and inhibits apoptosis in nerve cells, protecting them from damage.
Anti-inflammatory and Antioxidant Effects:
Has anti-inflammatory properties by reducing the secretion of inflammatory cytokines.
Acts as an antioxidant, protecting cells from oxidative damage.
Cognitive and Memory Support:
Improves cognitive function and memory, especially in animal models, showing positive effects on long-term functional outcomes such as memory.
May support neurohealth by regulating the activity of nerve growth factors.
Other Functions:
Serves as a precursor for acetylcholine, participating in the synthesis of neurotransmitters.
Helps regulate gene expression and modulate the activity of proteins and enzymes through acetylation.
Application
Nutritional Supplements:
Commonly used in dietary supplements to support energy metabolism and neurological health.
Treatment of Neurological Diseases:
Used in the treatment of neurodegenerative diseases (such as Alzheimer’s disease), nerve damage (such as traumatic brain injury), and neuropathic pain.
Shows potential in improving diabetic neuropathy and chemotherapy-induced peripheral neuropathy.
Cardiovascular Health:
May benefit cardiovascular health due to its role in energy metabolism.
Sports Performance:
As an aid in energy metabolism, it may help improve sports performance and recovery.
Other Applications:
Being explored in research for its potential benefits in managing stress-related disorders.