Acetyl L Carnitine

Acetyl-L-Carnitine (ALCAR) is an acetylated derivative of L-Carnitine, a naturally occurring compound that can cross the blood-brain barrier and has multiple physiological functions.

Description

Function

  1. Energy Metabolism:
    • Acts as an acetyl donor to promote the transfer of fatty acids from the cytoplasm to the mitochondria, participating in the beta-oxidation of fatty acids to provide energy for cells.
    • Helps maintain the balance of coenzyme A and acetyl-CoA within cells, supporting normal energy metabolism.
  2. Neuroprotection and Repair:
    • Exhibits neuroprotective effects by promoting nerve regeneration and axonal growth, improving nerve conduction velocity.
    • Shows significant protective effects in models of neurodegenerative diseases such as Alzheimer’s disease, ischemia-hypoxia, and traumatic brain injury.
    • Reduces oxidative stress and inhibits apoptosis in nerve cells, protecting them from damage.
  3. Anti-inflammatory and Antioxidant Effects:
    • Has anti-inflammatory properties by reducing the secretion of inflammatory cytokines.
    • Acts as an antioxidant, protecting cells from oxidative damage.
  4. Cognitive and Memory Support:
    • Improves cognitive function and memory, especially in animal models, showing positive effects on long-term functional outcomes such as memory.
    • May support neurohealth by regulating the activity of nerve growth factors.
  5. Other Functions:
    • Serves as a precursor for acetylcholine, participating in the synthesis of neurotransmitters.
    • Helps regulate gene expression and modulate the activity of proteins and enzymes through acetylation.

Application

  1. Nutritional Supplements:
    • Commonly used in dietary supplements to support energy metabolism and neurological health.
  2. Treatment of Neurological Diseases:
    • Used in the treatment of neurodegenerative diseases (such as Alzheimer’s disease), nerve damage (such as traumatic brain injury), and neuropathic pain.
    • Shows potential in improving diabetic neuropathy and chemotherapy-induced peripheral neuropathy.
  3. Cardiovascular Health:
    • May benefit cardiovascular health due to its role in energy metabolism.
  4. Sports Performance:
    • As an aid in energy metabolism, it may help improve sports performance and recovery.
  5. Other Applications:
    • Being explored in research for its potential benefits in managing stress-related disorders.