Description

Function

• Energy Metabolism: Niacin is a vital component of coenzyme 1 (NAD) and coenzyme 2 (NADP), which are involved in essential oxidation-reduction reactions. These reactions are crucial for glycolysis, protein and amino acid metabolism, fatty acid metabolism, and the synthesis of high-energy phosphate bonds.
• Lipid Regulation: Niacin is highly effective in managing dyslipidemia. It reduces total cholesterol, LDL cholesterol, and triglycerides while increasing HDL cholesterol levels.
• Skin Health: Niacin helps improve skin conditions and is used to treat dermatological symptoms associated with niacin deficiency.
• Neurological Support: It plays a role in maintaining neurological health and is used to treat pellagra, a condition caused by niacin deficiency.
• Cardiovascular Health: Niacin may reduce the risk of cardiovascular disease through its lipid-lowering effects and anti-inflammatory actions.

Application

• Dyslipidemia Management: Niacin is FDA-approved for treating hyperlipidemia (types IIa and IIb) and is used to reduce elevated cholesterol and triglyceride levels.
• Pellagra Treatment: It is used off-label to treat pellagra, a condition characterized by dermatitis, diarrhea, and dementia due to niacin deficiency.
• Supplements: Available in immediate-release, extended-release, and sustained-release formulations for dietary supplementation.
• Adjunct Therapy: Niacin is used as an adjunct to statins for patients with hyperlipidemia and as an alternative for those intolerant to statins.