Description

Function

• Metabolic Regulation:

Amino Acid Metabolism: PLP acts as a cofactor for enzymes involved in transamination, decarboxylation, and other amino acid transformations, playing a vital role in protein synthesis and breakdown.

Carbohydrate and Lipid Metabolism: It assists in the metabolism of carbohydrates and lipids, including the synthesis of neurotransmitters like dopamine and serotonin.

• Neurological Health:

PLP is involved in the synthesis of neurotransmitters (e.g., dopamine and serotonin), which are critical for maintaining healthy brain function. It has been shown to alleviate cognitive impairments in animal models, such as spatial and long-term memory deficits induced by Aβ25-35.

• Antioxidant and Anti-inflammatory Effects:

PLP has antioxidant properties and can inhibit the proliferation of certain cancer cells, as demonstrated in cell lines like SK-OV-3 and OVCAR-3.

• Other Biological Roles:

It helps in the regulation of gene expression and is involved in the prevention of diabetes and related complications.

Application

• Nutritional Supplements:

PLP is used as a dietary supplement to support overall health, particularly for individuals with vitamin B6 deficiencies.

• Pharmaceuticals:

It is used in the treatment of conditions such as tardive dyskinesia and to prevent complications in diabetes.

PLP is also used in research to study enzyme mechanisms and metabolic pathways.

• Research and Biocatalysis:

PLP-dependent enzymes are used in biocatalysis for the synthesis of natural and non-natural amino acids and related compounds。

• Cosmetics and Personal Care:

Due to its antioxidant properties, PLP may be used in cosmetic formulations to support skin health.